EX-99.1 2 tm2515261d1_ex99-1.htm EXHIBIT 99.1

Exhibit 99.1

 

 

 

Applied DNA Reports Second Quarter Fiscal 2025 Financial Results

 

- Therapeutic DNA Production Services Segment (LineaRx) Revenues Up 44% Y/Y, Contributing to a 6% Increase in Total Revenues -

 

- Intra-Quarter Investor Conference Call and Webcast Scheduled for June 3, 2025, at 4:30 PM ET -

 

STONY BROOK, N.Y. – May 15, 2025 - Applied DNA Sciences, Inc. (NASDAQ: APDN) (“Applied DNA” or the “Company”), a leader in PCR-based DNA technologies, today reported financial results for its second quarter of fiscal 2025 ended March 31, 2025.

 

The Company’s Form 10-Q for its fiscal second quarter can be viewed on the SEC Filings page of its Investor Relations website. To align with the Company’s Annual Meeting of Stockholders on May 22 and ensure a comprehensive post-meeting update, the quarterly investor call will be held on June 3, on which management will update investors on the Company’s strategic priorities.

 

Management Commentary

 

“Amidst a challenging macro environment with regulatory headwinds and volatile equity markets, we concluded a strategic reset and have emerged more focused, leaner, and positioned to meet biopharma’s emergent demand for enzymatic DNA with our LineaRx subsidiary positioned as what we believe to be North America’s largest, PCR-based producer of cell-free DNA,” stated Dr. James A. Hayward, chairman and CEO of Applied DNA. “Our strategic priority going forward is to elevate the execution of LineaRx and Applied DNA Clinical Labs in a way that drives consistent and recurring revenues to support higher gross margins and build shareholder value.

 

“Looking ahead, we believe industry tailwinds are accelerating,” Dr. Hayward concluded. “The biopharma industry is announcing substantial, planned investments in U.S. manufacturing; AI drug design is shortening genetic medicine development timelines, but persistent manufacturing bottlenecks tied to plasmid DNA’s technical constraints remain; and limitations regarding the scalability, efficiency, and cost constraints of competing enzymatic DNA technologies we believe offer market opportunities. With initial capital investments for our now operational Site 1 GMP facility complete, we believe our rapid DNA production and domestic sourcing capabilities are key differentiators to drive new customer acquisition.”

 

 

 

 

Recent Corporate and Operational Updates

 

Corporate:

 

·With the completion of its strategic restructuring, the Company expects quarterly cash burn to begin to decline beginning in the quarter ending June 30, 2025.

 

LineaRx (Therapeutic DNA Production and Services subsidiary):

 

·Validated GMP Site 1 manufacturing operations in January with production capabilities sufficient to support anticipated near-term manufacturing needs. Site 1 can support an annual revenue capacity between $10 million and $30 million, contingent on product mix and pricing.

 

·New customers added:

 

oA quantity of Research Use Only (RUO)-grade LineaDNA™ IVT templates and associated LineaRNAP™ for a U.S.-based mRNA contract development and manufacturing organization (CDMO).

 

oRUO-grade quantities of LineaDNA for in vitro studies to support four animal health vaccine candidates, with one LineaDNA construct proceeding to an in vivo study.

 

·Received follow-on orders from existing customers, notably:

 

oA quantity of RUO-grade LineaDNA IVT templates to an APAC-based CDMO of mRNA vaccines and therapeutics.

 

oA quantity of LineaDNA to a U.S.-based CRISPR and mRNA therapeutics developer.

 

oContinued large-scale manufacturing and delivery of LineaDNA under supply agreements with global manufacturers of in vitro diagnostics (IVDs).

 

·Engagement with a U.S.-based therapeutics developer on a challenging self-amplifying mRNA therapy did not result in a first GMP order, though our dialogue remains active for subsequent projects.

 

·Nearing completion of a proprietary enzyme and buffer system designed to enhance LinearDNA’s performance by boosting yields, lowering costs, and enabling production of longer, more complex DNA sequences, such as sa-mRNA. Large-scale manufacturing of the enzyme and buffer by a U.S.-based CDMO is expected to begin in June 2025.

 

·Expected to launch in Q4’25, LineaPCR™ is an offering to enable customers to self-manufacture LineaDNA with an easy, end-to-end process to simplify existing multi-week, multi-vendor, PCR-based drug discovery workflows.

 

·Launching LineaDNA IVT Evaluation Kits – three 25μg templates and associated LineaRNAP aimed at driving adoption of the LineaIVT platform by showcasing its advantages over plasmid-based systems and accelerating customer engagement in mRNA manufacturing. Kits will be offered at industry conferences and on LineaRxDNA.com.

 

 

 

 

Applied DNA Clinical Labs (MDx Testing Services subsidiary):

 

·Submitted a validation package to the New York State Department of Health (NYSDOH) for a PCR-based H5N1 diagnostic as a laboratory-developed test for the detection and subtyping of H5 bird flu, which is currently under review by NYSDOH.

 

·Introduced TR8™ PGx pharmacogenomic sub-panels for indication-specific use, complementing full-panel testing. The sub-panels are designed to lower adoption barriers for institutions, clinicians, and patients. The first sub-panel launched is TR8 PGx for Pre-emptive Oncology Care relating to fluoropyrimidine-based cancer therapeutics.

 

Second Quarter Fiscal 2025 Financial Highlights

 

·Total revenues: $983 thousand, compared to $930 thousand for the second quarter of fiscal 2024. Segment information is detailed in the ‘Note H – Segment Information’ section of the Form 10-Q for the period reported:

 

oTherapeutic DNA Production (LineaRx) segment revenues increased 44% compared to the same period of fiscal 2024. The increase in segment revenues was driven by a large shipment to a large-scale DNA manufacturing customer, as well as the timing of shipments for a second large-scale DNA manufacturing customer.

 

oMDx Testing Services (Applied DNA Clinical Labs) segment revenues decreased 33% compared to the same period of fiscal 2024 due to a decrease from COVID-19 surveillance testing.

 

·Operating loss: $3.5 million, compared to an operating loss of $3.6 million for the second quarter of fiscal 2024.

 

·Net loss: $3.3 million, compared to a net loss of $4.5 million for the second quarter of fiscal 2024. The improvement in net loss primarily reflects a loss on the issuance of warrants in the prior period that was not repeated in the reported quarter.

 

·Adjusted EBITDA: Negative $3.3 million, compared to negative $3.3 million for the second quarter of fiscal 2024.

 

·Cash and cash equivalents as of March 31, 2025: $6.8 million, which includes $1.0 million of proceeds from the exercise of Series A warrants.

 

 

 

 

June 3 Intra-Quarter Investor Conference Call Information

 

Management will hold a conference call to review the Company’s strategic priorities on June 3, 2025, at 4:30 p.m. Eastern Time. To participate in the conference call, please follow the instructions below. While every attempt will be made to answer investors’ questions on the Q&A portion of the call, not all questions may be answered.

 

An accompanying slide presentation will be embedded in the webcast (live and replay) that can also be accessed via the ‘Company Presentations’ page of the Applied DNA investor relations website.

 

To participate, please ask to be joined to the ‘Applied DNA Sciences’ call:

 

·Domestic callers (toll free): 844-887-9402

 

·International callers: 412-317-6798

 

·Canadian callers (toll free): 866-605-3852

 

·Live and replay of webcast: link

 

Telephonic replay (available 1 hour following the conclusion of the live call through June 10, 2025):

 

·Domestic callers (toll free): 1-877-344-7529

 

·Canadian callers (toll free): 1-855-669-9658

 

·Replay access code: 3446494

 

Information about Non-GAAP Financial Measures

 

As used herein, “GAAP” refers to accounting principles generally accepted in the United States of America. To supplement our condensed consolidated financial statements prepared and presented in accordance with GAAP, this earnings release includes Adjusted EBITDA, which is a non-GAAP financial measure as defined in Rule 101 of Regulation G promulgated by the Securities and Exchange Commission. Generally, a non-GAAP financial measure is a numerical measure of a company’s historical or future performance, financial position, or cash flows that either excludes or includes amounts that are not normally excluded or included in the most directly comparable measure calculated and presented in accordance with GAAP. The presentation of this non-GAAP financial information is not intended to be considered in isolation or as a substitute for, or superior to, the financial information presented in accordance with GAAP. We use this non-GAAP financial measure for internal financial and operational decision-making purposes and as a means to evaluate period-to-period comparisons of the performance and results of operations of our core businesses. Our management believes that these non-GAAP financial measures provide meaningful supplemental information regarding the performance of our businesses by excluding non-cash expenses that may not be indicative of our recurring operating results. We believe this non-GAAP financial measure is useful to investors as they allow for greater transparency with respect to key metrics used by management in its financial and operational decision making.

 

“EBITDA”- is defined as earnings (loss) before interest expense, income tax expense and depreciation and amortization expense.

 

“Adjusted EBITDA”- is defined as EBITDA adjusted to exclude (i) stock-based compensation and (ii) other non-cash expenses and non-cash gains/income.

 

 

 

 

About the LineaDNA™ and Linea IVT™ Platforms

 

The Linea DNA platform is an entirely cell-free DNA production platform founded on Applied DNA's long-standing expertise in the large-scale enzymatic production of DNA. Capable of producing DNA in quantities ranging from milligrams to grams, the Linea DNA platform can produce high-fidelity DNA constructs ranging from 100bp to 20kb in size. The DNA produced via the Linea DNA platform is free of the adventitious DNA sequences found in other sources of DNA, is rapidly scalable, and provides for simple chemical modification of DNA constructs. The Linea IVT platform combines DNA IVT templates manufacturing via the Linea DNA platform with a proprietary Linea™ RNAP to enable mRNA and sa-mRNA manufacturers to produce what Applied DNA believes to be better mRNA faster, with advantages over conventional mRNA production, including: 1) the elimination of plasmid DNA as a starting material; 2) the prevention or reduction of double-stranded DNA (dsRNA) contamination; and 3) simplified mRNA production workflows.

 

About Applied DNA Sciences

 

Applied DNA Sciences is a biotechnology company developing technologies to produce and detect deoxyribonucleic acid ("DNA"). Using the polymerase chain reaction ("PCR") to enable both the production and detection of DNA, we operate in two business markets: (i) the enzymatic manufacture of synthetic DNA for use in the production of nucleic acid-based therapeutics and the development and sale of a proprietary RNA polymerase ("RNAP") for use in the production of mRNA therapeutics; and (ii) the detection of DNA and RNA in molecular diagnostics and genetic testing services.

 

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Forward-Looking Statements

 

The statements made by Applied DNA in this press release may be “forward-looking” in nature within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. Forward-looking statements describe Applied DNA’s future plans, projections, strategies, and expectations, and are based on assumptions and involve a number of risks and uncertainties, many of which are beyond the control of Applied DNA. These forward-looking statements are based largely on the Company's expectations and projections about future events and future trends affecting our business and are subject to risks and uncertainties that could cause actual results to differ materially from those anticipated in the forward-looking statements, including statements regarding its goal to position the Company for long-term growth and value creation and the potential to achieve that goal, including the future success of its Linea DNA and Linea IVT platforms. Actual results could differ materially from those projected due to its history of net losses, limited financial resources, unknown future ability to remain compliant with all Nasdaq listing standards, unknown future demand for its biotherapeutics products and services, the unknown amount of revenues and profits that will result from its Linea IVT and/or Linea DNA platforms, the fact that there has never been clinical trial material and/or a commercial drug product produced utilizing the LineaDNA and/or Linea IVT platforms, the unknown amount of revenues and profits that will result from its current and planned future ADCL testing services, whether its restructuring will position the Company for future growth potential, as well as various other factors detailed from time to time in Applied DNA’s SEC reports and filings, including its Annual Report on Form 10-K filed on December 17, 2024, Forms 10-Q filed on February 13, 2025 and May 15, 2025, and other reports it files with the SEC, which are available at www.sec.gov. Applied DNA undertakes no obligation to update publicly any forward-looking statements to reflect new information, events, or circumstances after the date hereof or to reflect the occurrence of unanticipated events, unless otherwise required by law.

 

Investor Relations contact: Sanjay M. Hurry, 917-733-5573, [email protected]

 

Web: www.adnas.com

 

X: APDN

 

- Financial Tables Follow -

 

 

 

 

APPLIED DNA SCIENCES, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

 

   March 31,   September 30, 
   2025   2024 
   (unaudited)     
ASSETS          
Current assets:          
Cash and cash equivalents  $6,823,260   $6,431,095 
Accounts receivable, net of allowance for credit losses of $82,723 and $75,000 at March 31, 2025 and September 30, 2024, respectively   689,887    362,013 
Inventories   348,866    438,592 
Prepaid expenses and other current assets   568,398    815,970 
Total current assets   8,430,411    8,047,670 
           
Property and equipment, net   683,887    553,233 
Other assets:          
Restricted cash   750,000    750,000 
Intangible assets   2,698,975    2,698,975 
Operating right of use asset   472,390    739,162 
Total assets  $13,035,663   $12,789,040 
           
LIABILITIES AND EQUITY          
           
Current liabilities:          
Accounts payable and accrued liabilities  $1,409,628   $1,793,427 
Operating lease liability, current   472,390    545,912 
Deferred revenue   12,285    58,785 
Total current liabilities   1,894,303    2,398,124 
           
Long term accrued liabilities   31,467    31,467 
Deferred revenue, long term   194,000    194,000 
Operating lease liability, long term   —    193,249 
Deferred tax liability, net   684,115    684,115 
Warrants classified as a liability   7,570    320,000 
Total liabilities   2,811,455    3,820,955 
           
Commitments and contingencies (Note G)          
           
Applied DNA Sciences, Inc. stockholders’ equity:          
Preferred stock, par value $0.001 per share; 10,000,000 shares authorized; -0- shares issued and outstanding as of March 31, 2025 and September 30, 2024   —    — 
Series A Preferred stock, par value $0.001 per share; 10,000,000 shares authorized; -0- issued and outstanding as of March 31, 2025 and September 30, 2024   —    — 
Series B Preferred stock, par value $0.001 per share; 10,000,000 shares authorized; -0- issued and outstanding as of March 31, 2025 and September 30, 2024   —    — 
           
Common stock, par value $0.001 per share; 200,000,000 shares authorized as of March 31, 2025 and September 30, 2024; 6,331,410 and 206,324 shares issued and outstanding as of March 31, 2025 and September 30, 2024, respectively   6,331    206 
Additional paid in capital   364,896,649    318,815,166 
Accumulated deficit   (354,442,994)   (309,672,755)
Applied DNA Sciences, Inc. stockholders’ equity   10,459,986    9,142,617 
Noncontrolling interest   (235,778)   (174,532)
Total equity   10,224,208    8,968,085 
           
Total liabilities and equity  $13,035,663   $12,789,040 

 

 

 

 

 

 

APPLIED DNA SCIENCES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(unaudited)

 

   Three months Ended March 31,   Six months Ended March 31, 
   2025   2024   2025   2024 
Revenues                    
Product revenues  $548,638   $393,125   $1,044,485   $700,442 
Service revenues   214,184    205,486    588,628    452,633 
Clinical laboratory service revenues   220,552    331,020    546,878    667,720 
Total revenues   983,374    929,631    2,179,991    1,820,795 
                     
Cost of product revenues   367,304    340,301    631,356    622,846 
Cost of clinical laboratory service revenues   245,223    293,679    493,681    671,201 
Total cost of revenues   612,527    633,980    1,125,037    1,294,047 
                     
Gross profit   370,847    295,651    1,054,954    526,748 
                     
Operating expenses:                    
Selling, general and administrative   2,983,284    3,000,208    5,616,382    6,084,557 
Research and development   849,358    913,194    1,864,368    1,849,009 
Total operating expenses   3,832,642    3,913,402    7,480,750    7,933,566 
                     
LOSS FROM OPERATIONS   (3,461,795)   (3,617,751)   (6,425,796)   (7,406,818)
                     
Interest income   60,340    15,352    131,780    48,676 
Transaction costs allocated to warrant liabilities   —    (633,198)   —    (633,198)
Unrealized gain on change in fair value of warrants classified as a liability   68,430    1,765,000    312,430    4,404,000 
Unrealized loss on change in fair value of warrants classified as a liability - warrant modification   —    (394,000)   —    (394,000)
Loss on issuance of warrants   —    (1,633,767)   —    (1,633,767)
Other (expense) income, net   (3,095)   4,581    (23,247)   (8,957)
                     
Loss before provision for income taxes   (3,336,120)   (4,493,783)   (6,004,833)   (5,624,064)
                     
Provision for income taxes   —    —    —    — 
                     
NET LOSS  $(3,336,120)  $(4,493,783)  $(6,004,833)  $(5,624,064)
                     
Less: Net loss attributable to noncontrolling interest   31,945    23,309    61,246    48,490 
NET LOSS attributable to Applied DNA Sciences, Inc.  $(3,304,175)  $(4,470,474)  $(5,943,587)  $(5,575,574)
Deemed dividend related to warrant modifications   (23,919,429)   (155,330)   (38,826,652)   (233,087)
NET LOSS attributable to common stockholders  $(27,223,604)  $(4,625,804)  $(44,770,239)  $(5,808,661)
Net loss per share attributable to common stockholders-basic and diluted  $(15.35)  $(265.45)  $(33.82)  $(373.55)
                     
Weighted average shares outstanding- basic and diluted   1,773,086    17,426    1,323,913    15,550 

 

 

 

 

APPLIED DNA SCIENCES, INC.

CALCULATION AND RECONCILIATION OF ADJUSTED EBITDA

(unaudited)

 

   Three Month Period Ended March 31, 
   2025   2024 
Net loss  $(3,336,120)  $(4,493,783)
Interest income   (60,340)   (15,352)
Depreciation and amortization   118,675    186,326 
Provision for bad debt   (2,300)   - 
Stock-based compensation expense   26,511    171,004 
Unrealized gain on change in fair value of warrants classified as a liability   (68,430)   (1,765,000)
Unrealized (loss) on change in fair value of warrants classified as a liability – warrant modification   -    394,000 
Transaction costs allocated to warrant liabilities   -    633,198 
Loss on issuance of warrants   -    1,633,767 
Total non-cash items   14,116    1,237,943 
Consolidated Adjusted EBITDA (loss)  $(3,322,004)  $(3,255,840)

 

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