Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We herebyconsent to the incorporation by reference in the Registration Statements on Form S-8(No. 333-261061) of Vaxxinity,Inc.

of our audit report dated March 24, 2022, relating to the consolidated financialstatements of Vaxxinity,Inc. appearing in this Form

10-K for the year ended December 31, 2021.

ArmaninoLLP

San Jose, California

March 24, 2022