Exhibit 23.1

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CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Registration Nos. 333-265496 and 333-257868) and Registration Statement on Form S-3 (Registration No. 333-268764) of Transcode Therapeutics, Inc. (the “Company”) of our report dated March 31, 2023, which includes an explanatory paragraph relating to the Company’s ability to continue as a going concern, relating to the financial statements of the Company as of and for the years ended December 31, 2022 and 2021, which appear in this Form 10-K.

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