1.

I have reviewed this Amendment No. 1 to the Annual Report on Form 10-K of Aprea Therapeutics, Inc. for the year ended December 31, 2022; and

2.

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report