Document

We consent to the incorporation by reference in Registration Statement on Form S-3-ASR (No. 333-237983) and Form S-8 (Nos. 333-269539, 333-220589, 333-252351, 333-262825) of our report dated February 28, 2022, with respect to the consolidated financial statements of Krystal Biotech, Inc. as of December 31, 2021 and for the years ended December 31, 2021 and 2020, included in this annual report on Form 10-K of Krystal Biotech, Inc. as of and for the year ended December 31, 2022.