Exhibit 17.5

From: Claire Byrne <[email protected]>
Sent: Thursday, April 14, 2022 7:34:29 PM
To: Brian Payne <[email protected]>
Subject: Resignation

Brian

Effective immediately, I hereby resign as Director of Cen Biotech Inc.  I no longer hold any positions with the company.

Joseph Byrne

Director – Cen Biotech Inc.