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Exhibit 32.1

CERTIFICATION

PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002, 18 U.S.C. SECTION 1350

In connection with the quarterly report on Form 10-Q of Orchid Island Capital,Inc. (the “Company”) for the period ended

September 30, 2022 to be filed with the Securities and ExchangeCommission on or about the date hereof (the ”Report”),

I, Robert E. Cauley, Chairman of the Board and Chief Executive Officer of the Company, certify, pursuant to Section 906

of the Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that:

1.

The Report fully complies with the requirements of Section 13(a) or 15(d)of the Securities Exchange Act of 1934, as

amended; and

2.

The information contained in the Report fairly presents, in allmaterial respects, the financial condition and results of

operations of the Company at the dates of, and for the periods coveredby, the Report.

It is not intended that this statement be deemed to be filed for purposes of theSecurities Exchange Act of 1934.

October 28, 2022

/s/ Robert E. Cauley

Robert E. Cauley,

Chairman of the Board and

Chief Executive Officer