NAME:

JURISDICTION OF INCORPORATION:

  Andromeda Biotech Limited

Israel

  Horizon European Products, LLC

Delaware

  Horizon Medicines LLC

Delaware

  Horizon Orphan LLC

Delaware

  Horizon Pharma Aon Limited

Ireland

  Horizon Pharma Capital Limited

Ireland

  Horizon Pharma Dó Limited

Ireland

  Horizon Pharma Finance Limited

Ireland

  Horizon Pharma Finance S.à.r.l

Luxembourg

  Horizon Pharma GmbH

Germany

  Horizon Pharma Holdings Limited

Ireland

  Horizon Pharma Investment Limited

Bermuda

  Horizon Pharma Ireland Limited

Ireland

  Horizon Pharma Israel Holding Corp. Ltd

Israel

  Horizon Pharma Rheumatology LLC

Delaware

  Horizon Pharma Switzerland GmbH

Switzerland

  Horizon Pharma Tepro, Inc

Delaware

  Horizon Pharma Treasury Limited

Ireland

  Horizon Pharma Trí Limited

Ireland

  Horizon Pharma USA, Inc.

Delaware

  Horizon Pharmaceutical LLC

Delaware

  Horizon Therapeutics, LLC

Delaware

  Horizon Pharma Services LLC

Delaware

  Hyperion Therapeutics Ireland Holding Limited

Ireland

  Hyperion Therapeutics Ireland Operating Limited

Ireland

  HZNP Canada Limited

Canada

  HZNP Bermuda LLC

Bermuda

  HZNP Limited

Ireland

  HZNP Medicines LLC

Bermuda

  HZNP Holdings LLC

Bermuda

  HZNP USA LLC

Delaware

  Misneach Europe LLC

Delaware