EX-23.1

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1)

Registration Statement (Form S-8 No. 333-199046) pertaining to the Amended and Restated 2008 Equity Incentive Plan and 2014 Omnibus Incentive Plan of ContraFect Corporation,

(2)

Registration Statements (Form S-8 Nos. 333-217943, 333-224834, 333-231439 and 333-246340) pertaining to the 2014 Omnibus Incentive Plan of ContraFect Corporation, and

(3)

Registration Statements (Form S-3 Nos. 333-228626, 333-238593 and 333-246359) of ContraFect Corporation;

of our report dated March 30, 2021, with respect to the consolidated financial statements of ContraFect Corporation included in this Annual Report (Form 10-K) for the year ended December 31, 2020.

/s/ Ernst & Young LLP

Hartford, Connecticut

March 30, 2021