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We hereby consent to the incorporation by reference in the Registration Statements on Form S-1 (No. 333-233632), Form S-3 (No. 333-236583) and Form S-8 (No. 333-213854, No. 333-219913, No. 333-233630, No. 333-233631, and No. 333-258743) of Novan, Inc. of our report dated February 18, 2022, relating to the consolidated financial statements, which appears in this Form 10-K. Our report contains an explanatory paragraph regarding the Company’s ability to continue as a going concern.