ocugenincbio6162025

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Visual Field 0 10 20 30 40 50 60 70 80 P ro p o rt io n o f R e s p o n d e rs 75% 6/8

• • • o ± Year 1 Year 2 -5 0 5 10 M e a n Δ L L V A ( ± S E M ) fr o m B a s e li n e Treated Eye Untreated Eye * p = 0.005 p = 0.021 * Year 1 Year 2 -5 0 5 10 M e a n Δ L L V A ( ± S E M ) fr o m B a s e li n e Treated Eye Untreated Eye * p = 0.005 p = 0.055

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0.0 0.5 1.0 1.5 12MM e a n C h a n g e ( ± S E M ) i n T o ta l A tr o p h y A re a f ro m B a s e li n e ( m m 2 ) Treated Eye Untreated Eye Baseline M3 M6 M12 -10 -5 0 5 10 M e a n C h a n g e i n B C V A (E T D R S ) fr o m B a s e li n e ( ± S E M ) Treated Eye Untreated Eye • • ± ± ± ± ± ± ±

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• • BL 3M 6M 9M 12M -25 -20 -15 -10 -5 0 5 10 M e a n c h a n g e i n L L V A (E T D R S ) fr o m B a s e li n e Treated Eye Untreated Eye ±