Subsidiary

Jurisdiction of Incorporation

Collegium Securities Corporation

Massachusetts

Collegium NF, LLC

Delaware

BioDelivery Sciences International, Inc.

Delaware

Arius Pharmaceuticals, Inc.

Delaware

Arius Two, Inc.

Delaware

Ironshore Therapeutics, Inc.

Cayman Islands

Ironshore Pharmaceuticals & Development, Inc.

Cayman Islands

Ironshore Pharmaceuticals Inc.

Delaware

Ironshore Pharmaceuticals Canada Inc.

Canada

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